U.S. stock indexes open sharply lower Wednesday morning to start April and a new quarter, as as President Donald Trump warned on Tuesday that a "very, very painful" two weeks are ahead as the COVID-19 pandemic continues. The Dow Jones Industrial Average /zigman2/quotes/210598065/realtime DJIA +0.12% opened down 889 points, or 4%, at 21,053, the S&P 500 index /zigman2/quotes/210599714/realtime SPX +0.31% retreated 3.7% at 2,488, while the Nasdaq Composite Index /zigman2/quotes/210598365/realtime COMP +1.03% gave up 3.1% to reach 7,469. Markets are coming off of their worst monthly losses since the 2008 financial crisis. And investors appear to be attempting to come to grips with the prospect of a long slog from out of the morass of a viral outbreak that is pushing the domestic and global economy into a recession. The White House on Tuesday released new projections for 100,000 to 240,000 deaths in the U.S. from the coronavirus pandemic even if current social-distancing guidelines are maintained. Meanwhile, the number of COVID-19 cases world-wide rose to 862,234 on Wednesday, while the number of deaths rose to 42,404 according to aggregated data from Johns Hopkins University. In economic news, Automatic Data Processing /zigman2/quotes/207661132/composite ADP +0.58% reported the U.S. economy shed 27,000 private-sector jobs in March, though the data is expected to be of little use in predicting the official unemployment numbers due on Friday due to distortions created by the pandemic.