Shares of Intercept Pharmaceuticals Inc. /zigman2/quotes/202434567/composite ICPT +3.69% were up 2.2% in premarket trading on Wednesday, the day after the company told investors that it planned to lay off 170 employees, which is one-quarter of its workforce, by the end of the year. The layoffs, which are expected to incur aggregate charges of $18 million, are in response to a complete response letter that Intercept received from the Food and Drug Administration in June for its experimental nonalcoholic steatohepatitis drug. Intercept said in a filing it still plans to pursue FDA approval of the investigational therapy. Shares of Intercept are down 64.1% year-to-date, compared with the S&P 500 /zigman2/quotes/210599714/realtime SPX +2.02% , which has gained 9.1%.


