press release

June 8, 2020, 9:40 a.m. EDT

Psychedelic-derived Therapies are Just What the Doctor Ordered to Address a Historic Mental Illness Epidemic

FN Media Group Presents Microsmallcap.com Market Commentary

NEW YORK, June 8, 2020 /PRNewswire/ -- While the global death toll caused by the pandemic is well-publicized, a lesser-known side effect of the ongoing pandemic is the historic rise in mental illness that it has generated. Due to the stress, suffering, and isolation caused by the disease,  depression is at a record high. But depression doesn't strike alone. With it comes anxiety, substance abuse, post-traumatic stress disorder, and suicide. To address these problems, select pharmaceutical companies are researching psychedelic-based medicines, which represent potentially the most significant innovation in mental health treatment since the development of prozac in the 1980s. While most pharma giants continue to push traditional mental health offerings, others—namely, Mind Medicine (MindMed) Inc. (neo:MMED) (otcqb:MMEDF), Champignon Brands /zigman2/quotes/216819817/delayed CA:SHRM +3.49% (otcqb:SHRMF), Numinus Wellness Inc /zigman2/quotes/204558261/delayed CA:NUMI -3.57% , Seelos Therapeutics, Inc. /zigman2/quotes/201189599/composite SEEL +2.73% , and Johnson & Johnson /zigman2/quotes/201724570/composite JNJ -0.38% — are using novel, psychedelic therapies to tackle the mental illness epidemic gripping millions of people.

Exploring the Therapeutic Applications of LSD, MDMA, and 18-MC

Of the pharmaceutical stocks working towards the commercial launch of psychedelic-derived therapies, the one with the most advanced and diversified portfolio is likely Mind Medicine Inc. (MMED.AQN) (MMEDF.QB). In March, it became the first psychedelics-focused pharmaceutical company to go public, choosing to list on the NEO exchange. As one would expect, there was considerable excitement surrounding the company's IPO.

Part of this excitement was that MindMed is a pure-play psychedelics stock. It is currently working towards the advancement of not just one, but several potential therapies derived from a handful of psychedelic drugs.

On April 1, the company signed a multi-year collaboration with the laboratory of Professor Dr. Matthias Liechti. Based out of Basel, Switzerland—which happens to be the birthplace of LSD—this laboratory is the world-leading psychedelics pharmacology and clinical research group.

Based on data it acquired from this collaboration, MindMed announced that it is launching Project Lucy to focus on LSD-based experiential therapy for anxiety disorders. The company intends to initiate a Phase 2b human efficacy trial that will focus on experiential or "hallucinogenic" doses of LSD, which will be administered by a therapist. This is the first experiential, psychedelic-assisted therapy to be added to the company's drug development pipeline.

But that's not the only application it hopes to explore with LSD. MindMed has also entered into a clinical trial agreement with Maastricht University to undertake a Phase 2a clinical trial for LSD in adult patients with ADHD. This work is being done through the company's Microdosing division, which was created to develop a portfolio of clinical trials studying the use of sub-perceptual amounts of psychedelic substances for medical purposes.

In addition to LSD, Mind Medicine Inc. (MMED.AQN) (MMEDF.QB) recently added the psychedelic compound MDMA to its research and development pipeline. This work is also based on research from the Liechti Lab, which, according to Dr. Liecht himself, has generated "a large amount of data on the pharmacokinetics, pharmacogenetics and safety of MDMA in over 10 years of clinical research." MDMA has previously received "breakthrough therapy" designation from the FDA. MindMed intends to create next-gen psychedelic therapies that combine MDMA and LSD.

The company is also exploring the therapeutic potential of 18-MC, a proprietary, non-hallucinogenic molecule based on the psychedelic ibogaine that it wants to create the "antibiotic of addiction" with. In extensive nonclinical testing, 18-MC has shown promise in helping to curb various forms of addiction, and MindMed is scheduled to begin Phase 2 trials of the drug in opioid use disorder patients later this year.

To ensure it is well funded and able to explore its various avenues of research, MindMed recently closed a short form prospectus offering. By issuing 24,953,850 units of the company at a price per unit of $0.53 CAD, it generated gross proceeds of $13,225,540.50 clearing the way for MindMed to focus exclusively on research, patents, and eventual commercialization. This now brings total funding the company has raised to just under USD$40 million.

The "Breakthrough" Potential of Psilocybin and Ketamine

Joining  Mind Medicine Inc. (MMED.AQN) (MMEDF.QB) in the race to develop psychedelic-derived therapies is Champignon Brands (otcqb:SHRMF) /zigman2/quotes/216819817/delayed CA:SHRM +3.49% , another pure-play in this space. Champignon is focused on exploring how medicines based on "magic" mushrooms can help people suffering from mental health issues. In particular, the company is exploring the potential for psilocybin—one of the primary components of magic mushrooms—to be used in treating PTSD. 

Also in Canada, recently listed Numinus Wellness Inc has received permission to research and retail MDMA, psilocybin, psilocin, and DMT. The company hopes to scale its model of operating stand-alone centers for patients with its health solutions in future acquisitions, though as of yet does not have any clinical trials underway, which is a key metric to evaluate companies in this space.

Last year, Seelos Therapeutics Inc. (NASDAQ: SEEL ) was awarded fast trackdesignation by the FDA for its investigational intranasal racemic ketamine program. This program explores ketamine—an anesthetic medication—for the treatment of Acute Suicidal Ideation and Behavior (ASIB) in patients with Major Depressive Disorder (MDD). According to Proactive Investors, Wall Street believes SEEL's ketamine-derived offering will "reach millions of patients with post-traumatic stress disorder (PTSD) and major depressive disorder (MDD)."

Likewise, the pharmaceutical giant Johnson & Johnson /zigman2/quotes/201724570/composite JNJ -0.38% is advancing a depression treatment based on esketamine, a chemical cousin of ketamine. Last year, the FDA approved a nasal-spray form of esketamine as a fast-acting treatment for patients who have failed to find relief with at least two antidepressants.

The Future of Mental Illness Treatment

Over the last few years, many institutions in the US and Canada have liberalized their views regarding the research and commercialization of psychedelic-derived therapies. One major example of this is the FDA's designation of psilocybin as a "breakthrough therapy," which will open the door for other psychedelic clinical trials from Mind Medicine Inc. (MMED.AQN) (MMEDF.QB) and its peers.

A recent study revealed that—of the 30.6 million American adults who reported using a benzodiazepine, such as alprazolam (the generic form of Xanax)—more than 17% admitted to misusing the medication. According to the National Institute on Drug Abuse, benzodiazepines are involved in more than 10,000 overdose deaths annually (most often when combined with an opioid)—a five-fold increase between 2002 and 2018.

Psychedelic-derived therapies represent a promising solution to this growing problem as a non-addictiveand potentially more effective alternative to traditional antidepressants and anxiety medications. What's more, the full potential of these medicines is still being explored. Investors should expect to see serious developments in both the research and commercialization of psychedelics over the next two to five years.

To learn more about Mind Medicine (MindMed) Inc. (neo:MMED) (otcqb:MMEDF) , click here.

Disclaimer:  Microsmallcap.com (MSC) is the source of the Article and content set forth above. MSC owns and operates Stockstreetnews.com.  References to any issuer other than the profiled issuer are intended solely to identify industry participants and do not constitute an endorsement of any issuer and do not constitute a comparison to the profiled issuer. FN Media Group (FNM) is a third-party publisher and news dissemination service provider, which disseminates electronic information through multiple online media channels. FNM is NOT affiliated with MSC or any company mentioned herein. The commentary, views and opinions expressed in this release by MSC are solely those of MSC and are not shared by and do not reflect in any manner the views or opinions of FNM. Readers of this Article and content agree that they cannot and will not seek to hold liable MSC and FNM for any investment decisions by their readers or subscribers. MSC and FNM and their respective affiliated companies are a news dissemination and financial marketing solutions provider and are NOT registered broker-dealers/analysts/investment advisers, hold no investment licenses and may NOT sell, offer to sell or offer to buy any security.

The Article and content related to the profiled company represent the personal and subjective views of the Author (MSC), and are subject to change at any time without notice. The information provided in the Article and the content has been obtained from sources which the Author believes to be reliable. However, the Author (MSC) has not independently verified or otherwise investigated all such information. None of the Author, MSC, FNM, or any of their respective affiliates, guarantee the accuracy or completeness of any such information. This Article and content are not, and should not be regarded as investment advice or as a recommendation regarding any particular security or course of action; readers are strongly urged to speak with their own investment advisor and review all of the profiled issuer's filings made with the Securities and Exchange Commission before making any investment decisions and should understand the risks associated with an investment in the profiled issuer's securities, including, but not limited to, the complete loss of your investment. FNM was not compensated by any public company mentioned herein to disseminate this press release but was compensated twenty five hundred dollars by MSC, a non-affiliated third party to distribute this release on behalf of Mind Medicine Inc.

FNM HOLDS NO SHARES OF ANY COMPANY NAMED IN THIS RELEASE.

This release contains "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E the Securities Exchange Act of 1934, as amended and such forward-looking statements are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. "Forward-looking statements" describe future expectations, plans, results, or strategies and are generally preceded by words such as "may", "future", "plan" or "planned", "will" or "should", "expected," "anticipates", "draft", "eventually" or "projected". You are cautioned that such statements are subject to a multitude of risks and uncertainties that could cause future circumstances, events, or results to differ materially from those projected in the forward-looking statements, including the risks that actual results may differ materially from those projected in the forward-looking statements as a result of various factors, and other risks identified in a company's annual report on Form 10-K or 10-KSB and other filings made by such company with the Securities and Exchange Commission. You should consider these factors in evaluating the forward-looking statements included herein, and not place undue reliance on such statements. The forward-looking statements in this release are made as of the date hereof and MSC and FNM undertake no obligation to update such statements.

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