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July 12, 2022, 9:46 a.m. EDT

Todos Medical Reports Case Study #7 in Acute and Long COVID

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Jul 12, 2022 (NewMediaWire via COMTEX) -- New York, NY, and Tel Aviv, ISRAEL - ( NewMediaWire ) - July 12, 2022 - Todos Medical, Ltd. (OTCQB: TOMDF), a comprehensive medical diagnostics and related solutions company, today announced that its majority-owned joint venture 3CL Pharma Ltd. reported the outcome from a sponsored case study overseen by Dr. Lee Morgentaler in concert with Andrew A. Blumenthal, RN ADS of a patient who was experiencing symptoms of Post-Acute Sequelae of COVID (PASC, or “Long COVID”) and subsequently was likely reinfected with SARS-CoV-2 virus and saw resolution of both pathologies following intervention with Tollovid®.

ABSTRACT

The subject is a 32-year-old, 5’ 9”, 146 pound female. She describes her pre-COVID baseline as healthy and fit. She attended 3 – 4 weekly fitness classes consisting of yoga, boxing, or running 2-4 miles. By report, subject was vaccinated with the JNJ vaccine on March 6, 2021. No adverse reactions were noted.

On December 18, 2021 the subject tested COVID-19 positive via an antigen lateral flow test. She experienced low-grade fever, chills and body aches for 2 days before extreme fatigue set in. She lost 7 lbs in 1 week. On December 27, 2021 her symptoms resolved and she was able to work remotely.

In March 2022 the subject experienced prodromal cold symptoms for a period of 2 weeks after which the symptoms more fully developed as she experienced profound fatigue, mild fever, flushed cheeks, clammy hands, and burning eyes. The unexplained symptoms prompted a visit to her primary healthcare provider who thought she either had thyroid issues or vitamin D deficiency. Pending bloodwork, the subject took the prescribed vitamin D supplementation and, over a period of two weeks, her symptoms ameliorated. Subsequent serology exams revealed the thyroid was functioning within normal parameters.

The subject accompanied 8 companions on a 2-day trip to Mexico. Four of the eight companions tested COVID-19 positive 2 days after returning to the United States. On May 3, 2022 the subject exhibited symptoms including, mild fever, clammy hands, burning eyes, and profound fatigue. She self-administered 2 rapid lateral flow antigen tests with a follow-up PCR test. Each test resulted negative for COVID-19. On May 7, 2022 the subject used an infrared sauna to detox and felt better the next day but the symptoms returned on May 9, 2022. The extreme fatigue made it impossible to work out as she had done in the past.

On May 20, 2022 the subject started a regimen of Tollovid Maximum Strength. She took 12 Tollovid capsules daily for 5 days, and saw her symptoms completely resolve in 3 – 4 days.

DISCUSSION:

This case study suggests there was underlying COVID-19 disease pathology not detected by traditional antigen and PCR tests. In March 2022, Long COVID symptoms developed as her immune system was actively trying to rid the body of pathogen. In May 2022, the subject was likely exposed to COVID-19 and then showed signs of extreme fatigue worse than her prior episode. The subject’s response to Tollovid may indicate viral persistence was the proximal cause of the disease pathogenesis. This is further evidence that the COVID-19 virus may remain active in hidden reservoirs and flare when presented with an immune challenge.

To purchase Tollovid please visit Amazon or www.MyTollovid.com .

About Tollovid® and Tollovid Daily™

Tollovid and Tollovid Daily are oral dietary supplement products made from natural ingredients that help support and maintain healthy immune function and also have potent 3CL protease inhibition properties based upon in vitro functional assays that show strong inhibition of 3CL protease activity. Tollovid's 3CL protease IC50 binding affinity is at least ten times (10x) as strong as Ivermectin’s published 3CL protease IC50 binding affinity. Tollovid Daily’s 3CL protease IC50 binding affinity is at least two and a half times (2.5x) as Ivermectin. Tollovid and Tollovid Daily bind to the active site (receptor binding domain) of the 3CL protease. Tollovid has a 5-day dosing regimen, with 4 doses of 3 pills taken each day that provides maximum immune support. Tollovid Daily is a daily immune support product with a dosing regimen of twice daily. Preliminary data from an ongoing IRB-waiver study of customers who used the products to assist with their COVID and Long COVID was recently announced.

To purchase Tollovid please visit Amazon or www.MyTollovid.com .

About Tollovir®

Tollovir® is an oral 3CL protease inhibitor and anti-cytokine therapeutic candidate for the intervention of the Nidovirus group of viruses that includes coronaviruses such as SARS-CoV-2, COVID-19, SARS-CoV-1, MERS and 229E. Tollovir is made from all natural ingredients that are qualified to ensure strong inhibition of the 3CL protease in vitro, as well as strong anti-cytokine activity. Tollovir has successfully completed a Phase 2 clinical trial in Israel for the treatment of patients hospitalized with COVID-19. Tollovir will be developed for the treatment of hospitalized COVID-19 (severe and critical), moderate COVID-19, long-haul COVID and potentially pediatric COVID-19. Todos has licensed rights for Tollovir to T-Cell Protect Hellas S.A. for the Greek market.

About Todos Medical Ltd.

Founded in Rehovot, Israel with offices in New York City, Todos Medical Ltd. (otcqb:TOMDF) engineers life-saving diagnostic solutions for the early detection of a variety of cancers. The Company's state-of-the-art and patented Todos Biochemical Infrared Analyses (TBIA) is a proprietary cancer-screening technology using peripheral blood analysis that examines cancer's influence on the immune system, looking for biochemical changes in blood mononuclear cells and plasma. Todos’ two internally developed cancer-screening tests, TMB-1 and TMB-2 have received a CE mark in Europe. Todos recently acquired U.S.-based medical diagnostics company Provista Diagnostics, Inc. to gain rights to its Alpharetta, Georgia-based CLIA/CAP certified lab currently performing PCR COVID testing and Provista's proprietary commercial-stage Videssa® breast cancer blood test.

Todos is also developing blood tests for the early detection of neurodegenerative disorders, such as Alzheimer's disease. The Lymphocyte Proliferation Test (LymPro Test™) is a diagnostic blood test that determines the ability of peripheral blood lymphocytes (PBLs) and monocytes to withstand an exogenous mitogenic stimulation that induces them to enter the cell cycle. It is believed that certain diseases, most notably Alzheimer's disease, are the result of compromised cellular machinery that leads to aberrant cell cycle re-entry by neurons, which then leads to apoptosis. LymPro is unique in the use of peripheral blood lymphocytes as a surrogate for neuronal cell function, suggesting a common relationship between PBLs and neurons in the brain.

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